Dexamethasone-induced cell death is restricted to specific molecular subgroups of Multiple Myeloma

Due to its cytotoxic effect in lymphoid cells, dexamethasone is widely used in the treatment of Multiple Myeloma. However, only a subset of myeloma patients responds to high-dose dexamethasone. Despite the undeniable anti-myeloma benefits of dexamethasone, significant adverse effects have been reported. The anti-tumor effect of dexamethasone was re-evaluated according to the molecular heterogeneity of Multiple Myeloma.